ADDRESSING THE CLINICAL BURDEN OF CLOSTRIDIUM DIFFICILE INFECTION (CDI): EVALUATION OF THE BURDEN, CURRENT PRACTICES AND SET-UP OF A EUROPEAN RESEARCH PLATFORM (PART OF THE IMI NEW DRUGS FOR BAD BUGS (ND4BB) PROGRAMME
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Infection with Clostridium difficile, a Gram-positive spore-forming anaerobe, is the most common cause of nosocomial diarrhoea in developed countries and leads to symptoms that range from self-limiting mild-moderate watery diarrhea to severe fulminant diarrhea, abdominal pain and pseudomembranous colitis. In some patients it may progress to toxic megacolon, colonic perforation and death.
The challenge is to specifically optimise technical bio-based production routes in a way that minimizes nutrient losses over the whole process chain caused by either processing and/or partial use of v...
Validate the technology for the utilisation of algae and other aquatic/marine biomass for the production of ingredients and proteins for food and feed, and of chemicals for pharmaceutical, cosmetics a...